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The US Treasury's Office of Foreign Assets Control (OFAC) amended the Cuban Assets Control Regulations (CACR) to exclude entities and sub-entities identified on the Cuba Restricted List from three remittance general licences: §515.570 (outbound remittances), §515.572(a)(3) (remittance forwarding services), and §515.587 (other authorised remittances). The rule additionally amended the ordinarily-incident provision §515.421 to confirm that transactions routed through Cuba Restricted List entities are not covered even where the underlying licence does not expressly exclude them. The effective date was 30 days after Federal Register publication, on 26 November 2020.

On 8 October 2020, the US Treasury's Office of Foreign Assets Control (OFAC) determined that section 1(a)(i) of Executive Order 13902 (10 January 2020) applies to the financial sector of the Iranian economy, exposing non-US persons that operate in or knowingly facilitate significant transactions with that sector to secondary sanctions. Concurrently, OFAC designated eighteen Iranian banks (sixteen under E.O. 13902, one as an owned-or-controlled affiliate, and Hekmat Iranian Bank under E.O. 13382 non-proliferation authority). After a 45-day wind-down, the secondary-sanctions exposure became effective on 22 November 2020. The determination was formally republished in the Federal Register on 1 October 2025 (FR Doc 2025-19123) under Trump 2.0's maximum-pressure restoration; the underlying economic measure dates to the 2020 action.

The U.S. Department of the Treasury's Office of Foreign Assets Control (OFAC) published the International Criminal Court-Related Sanctions Regulations as an interim final rule effective 1 October 2020, codifying into 31 CFR Part 520 the IEEPA-based asset-blocking authorities delegated by President Trump's Executive Order 13928 of 11 June 2020. The regulations authorised OFAC to block the property and property interests of persons determined to have materially assisted, sponsored, or supported ICC efforts to investigate, arrest, detain, or prosecute any U.S. or allied-nation personnel without consent. No individual designations were made under 31 CFR Part 520 before the programme was terminated by President Biden's EO 14022 in April 2021 and OFAC struck the part from the CFR effective 6 July 2021.

The US Treasury's Office of Foreign Assets Control (OFAC) amended the Cuban Assets Control Regulations (31 CFR Part 515) effective 24 September 2020 to further deny the Cuban regime revenue. The rule added a new prohibition on lodging at any property on the State Department's Cuba Prohibited Accommodations List (PAL) and removed the general licence permitting travellers to import Cuban-origin alcohol and tobacco products as accompanied baggage. It also narrowed the professional meetings and conferences general licence (515.564) and the public performances, clinics, workshops, competitions, and exhibitions general licence (515.575) to exclude Cuba-related activities, closing gaps exploited under earlier travel-authorisation categories.